The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses
Identifieur interne : 001543 ( Main/Exploration ); précédent : 001542; suivant : 001544The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses
Auteurs : Diego Forni [Italie] ; Giulia Filippi [Italie] ; Rachele Cagliani [Italie] ; Luca De Gioia [Italie] ; Uberto Pozzoli [Italie] ; Nasser Al-Daghri ; Mario Clerici [Italie] ; Manuela Sironi [Italie]Source :
- Scientific Reports [ 2045-2322 ] ; 2015.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Coronavirus (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Données de séquences moléculaires, Gènes viraux, Génotype, Humains, Phylogénie, Recombinaison génétique, Sélection génétique, Séquence d'acides aminés, Séquences répétées d'acides nucléiques, Variation génétique, Évolution moléculaire.
- MESH :
- génétique : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- Alignement de séquences, Animaux, Données de séquences moléculaires, Gènes viraux, Génotype, Humains, Phylogénie, Recombinaison génétique, Sélection génétique, Séquence d'acides aminés, Séquences répétées d'acides nucléiques, Variation génétique, Évolution moléculaire.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Coronavirus (genetics), Evolution, Molecular, Genes, Viral, Genetic Variation, Genotype, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Molecular Sequence Data, Phylogeny, Recombination, Genetic, Repetitive Sequences, Nucleic Acid, Selection, Genetic, Sequence Alignment.
- MESH :
- genetics : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- Amino Acid Sequence, Animals, Evolution, Molecular, Genes, Viral, Genetic Variation, Genotype, Humans, Molecular Sequence Data, Phylogeny, Recombination, Genetic, Repetitive Sequences, Nucleic Acid, Selection, Genetic, Sequence Alignment.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) originated in bats and spread to humans via zoonotic transmission from camels. We analyzed the evolution of the
The online version of this article (doi:10.1038/srep14480) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/srep14480
PubMed: 26404138
PubMed Central: 4585914
Affiliations:
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Le document en format XML
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MEDEA, Bioinformatics, 23842 Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini</wicri:regionArea><wicri:noRegion>23842 Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Filippi, Giulia" sort="Filippi, Giulia" uniqKey="Filippi G" first="Giulia" last="Filippi">Giulia Filippi</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.7563.7</institution-id><institution-id institution-id-type="ISNI">0000 0001 2174 1754</institution-id><institution>Department of Biotechnology and Biosciences,</institution><institution>University of Milan-Bicocca,</institution></institution-wrap>Milan, 20126 Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Cagliani, Rachele" sort="Cagliani, Rachele" uniqKey="Cagliani R" first="Rachele" last="Cagliani">Rachele Cagliani</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Scientific Institute IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini</wicri:regionArea><wicri:noRegion>23842 Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="De Gioia, Luca" sort="De Gioia, Luca" uniqKey="De Gioia L" first="Luca" last="De Gioia">Luca De Gioia</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.7563.7</institution-id><institution-id institution-id-type="ISNI">0000 0001 2174 1754</institution-id><institution>Department of Biotechnology and Biosciences,</institution><institution>University of Milan-Bicocca,</institution></institution-wrap>Milan, 20126 Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Pozzoli, Uberto" sort="Pozzoli, Uberto" uniqKey="Pozzoli U" first="Uberto" last="Pozzoli">Uberto Pozzoli</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Scientific Institute IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini</wicri:regionArea><wicri:noRegion>23842 Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Al Daghri, Nasser" sort="Al Daghri, Nasser" uniqKey="Al Daghri N" first="Nasser" last="Al-Daghri">Nasser Al-Daghri</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.56302.32</institution-id><institution-id institution-id-type="ISNI">0000 0004 1773 5396</institution-id><institution>Biomarkers research program, Biochemistry Department,</institution><institution>College of Science, King Saud University,</institution></institution-wrap>Riyadh, 11451 (KSA) Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">11451 (KSA) Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.56302.32</institution-id><institution-id institution-id-type="ISNI">0000 0004 1773 5396</institution-id><institution>Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department,</institution><institution>College of science, King Saud University,</institution></institution-wrap>Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.4708.b</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 2822</institution-id><institution>Department of Physiopathology and Transplantation,</institution><institution>University of Milan,</institution></institution-wrap>Milan, 20090 Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.414603.4</institution-id><institution>Don C. Gnocchi Foundation ONLUS, IRCCS,</institution></institution-wrap>Milan, 20148 Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Sironi, Manuela" sort="Sironi, Manuela" uniqKey="Sironi M" first="Manuela" last="Sironi">Manuela Sironi</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Scientific Institute IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini</wicri:regionArea><wicri:noRegion>23842 Bosisio Parini</wicri:noRegion></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Coronavirus (genetics)</term><term>Evolution, Molecular</term><term>Genes, Viral</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Recombination, Genetic</term><term>Repetitive Sequences, Nucleic Acid</term><term>Selection, Genetic</term><term>Sequence Alignment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Coronavirus (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Données de séquences moléculaires</term><term>Gènes viraux</term><term>Génotype</term><term>Humains</term><term>Phylogénie</term><term>Recombinaison génétique</term><term>Sélection génétique</term><term>Séquence d'acides aminés</term><term>Séquences répétées d'acides nucléiques</term><term>Variation génétique</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Evolution, Molecular</term><term>Genes, Viral</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Recombination, Genetic</term><term>Repetitive Sequences, Nucleic Acid</term><term>Selection, Genetic</term><term>Sequence Alignment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Gènes viraux</term><term>Génotype</term><term>Humains</term><term>Phylogénie</term><term>Recombinaison génétique</term><term>Sélection génétique</term><term>Séquence d'acides aminés</term><term>Séquences répétées d'acides nucléiques</term><term>Variation génétique</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) originated in bats and spread to humans via zoonotic transmission from camels. We analyzed the evolution of the <italic>spike</italic> (<italic>S</italic>) gene in betacoronaviruses (betaCoVs) isolated from different mammals, in bat coronavirus populations, as well as in MERS-CoV strains from the current outbreak. Results indicated several positively selected sites located in the region comprising the two heptad repeats (HR1 and HR2) and their linker. Two sites (R652 and V1060) were positively selected in the betaCoVs phylogeny and correspond to mutations associated with expanded host range in other coronaviruses. During the most recent evolution of MERS-CoV, adaptive mutations in the HR1 (Q/R/H1020) arose in camels or in a previous host and spread to humans. We determined that different residues at position 1020 establish distinct inter- and intra-helical interactions and affect the stability of the six-helix bundle formed by the HRs. A similar effect on stability was observed for a nearby mutation (T1015N) that increases MERS-CoV infection efficiency <italic>in vitro</italic>. Data herein indicate that the heptad repeat region was a major target of adaptive evolution in MERS-CoV-related viruses; these results are relevant for the design of fusion inhibitor peptides with antiviral function.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1038/srep14480) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Xc" uniqKey="Tang X">XC Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Debnath, Ak" uniqKey="Debnath A">AK Debnath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Lin, K" uniqKey="Lin K">K Lin</name></author><author><name sortKey="Strick, N" uniqKey="Strick N">N Strick</name></author><author><name sortKey="Neurath, Ar" uniqKey="Neurath A">AR Neurath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longdon, B" uniqKey="Longdon B">B Longdon</name></author><author><name sortKey="Brockhurst, Ma" uniqKey="Brockhurst M">MA Brockhurst</name></author><author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name></author><author><name sortKey="Welch, Jj" uniqKey="Welch J">JJ Welch</name></author><author><name sortKey="Jiggins, Fm" uniqKey="Jiggins F">FM Jiggins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anisimova, M" uniqKey="Anisimova M">M Anisimova</name></author><author><name sortKey="Nielsen, R" uniqKey="Nielsen R">R Nielsen</name></author><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name></author><author><name sortKey="Posada, D" uniqKey="Posada D">D Posada</name></author><author><name sortKey="Gravenor, Mb" uniqKey="Gravenor M">MB Gravenor</name></author><author><name sortKey="Woelk, Ch" uniqKey="Woelk C">CH Woelk</name></author><author><name sortKey="Frost, Sd" uniqKey="Frost S">SD Frost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Nielsen, R" uniqKey="Nielsen R">R Nielsen</name></author><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gharib, Wh" uniqKey="Gharib W">WH Gharib</name></author><author><name sortKey="Robinson Rechavi, M" uniqKey="Robinson Rechavi M">M Robinson-Rechavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murrell, B" uniqKey="Murrell B">B Murrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, Y" uniqKey="Yamada Y">Y Yamada</name></author><author><name sortKey="Liu, Xb" uniqKey="Liu X">XB Liu</name></author><author><name sortKey="Fang, Sg" uniqKey="Fang S">SG Fang</name></author><author><name sortKey="Tay, Fp" uniqKey="Tay F">FP Tay</name></author><author><name sortKey="Liu, Dx" uniqKey="Liu D">DX Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author><author><name sortKey="Hingley, St" uniqKey="Hingley S">ST Hingley</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Dj" uniqKey="Wilson D">DJ Wilson</name></author><author><name sortKey="Mcvean, G" uniqKey="Mcvean G">G McVean</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schymkowitz, J" uniqKey="Schymkowitz J">J Schymkowitz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Capriotti, E" uniqKey="Capriotti E">E Capriotti</name></author><author><name sortKey="Fariselli, P" uniqKey="Fariselli P">P Fariselli</name></author><author><name sortKey="Casadio, R" uniqKey="Casadio R">R Casadio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Privman, E" uniqKey="Privman E">E Privman</name></author><author><name sortKey="Penn, O" uniqKey="Penn O">O Penn</name></author><author><name sortKey="Pupko, T" uniqKey="Pupko T">T Pupko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcroy, Wc" uniqKey="Mcroy W">WC McRoy</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pacheco, B" uniqKey="Pacheco B">B Pacheco</name></author><author><name sortKey="Basmaciogullari, S" uniqKey="Basmaciogullari S">S Basmaciogullari</name></author><author><name sortKey="Labonte, Ja" uniqKey="Labonte J">JA Labonte</name></author><author><name sortKey="Xiang, Sh" uniqKey="Xiang S">SH Xiang</name></author><author><name sortKey="Sodroski, J" uniqKey="Sodroski J">J Sodroski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mori, K" uniqKey="Mori K">K Mori</name></author><author><name sortKey="Rosenzweig, M" uniqKey="Rosenzweig M">M Rosenzweig</name></author><author><name sortKey="Desrosiers, Rc" uniqKey="Desrosiers R">RC Desrosiers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eggink, D" uniqKey="Eggink D">D Eggink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suntoke, Tr" uniqKey="Suntoke T">TR Suntoke</name></author><author><name sortKey="Chan, Dc" uniqKey="Chan D">DC Chan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loytynoja, A" uniqKey="Loytynoja A">A Loytynoja</name></author><author><name sortKey="Goldman, N" uniqKey="Goldman N">N Goldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Penn, O" uniqKey="Penn O">O Penn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anisimova, M" uniqKey="Anisimova M">M Anisimova</name></author><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guindon, S" uniqKey="Guindon S">S Guindon</name></author><author><name sortKey="Delsuc, F" uniqKey="Delsuc F">F Delsuc</name></author><author><name sortKey="Dufayard, Jf" uniqKey="Dufayard J">JF Dufayard</name></author><author><name sortKey="Gascuel, O" uniqKey="Gascuel O">O Gascuel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anisimova, M" uniqKey="Anisimova M">M Anisimova</name></author><author><name sortKey="Bielawski, Jp" uniqKey="Bielawski J">JP Bielawski</name></author><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name></author><author><name sortKey="Frost, Sd" uniqKey="Frost S">SD Frost</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Delport, W" uniqKey="Delport W">W Delport</name></author><author><name sortKey="Poon, Af" uniqKey="Poon A">AF Poon</name></author><author><name sortKey="Frost, Sd" uniqKey="Frost S">SD Frost</name></author><author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tina, Kg" uniqKey="Tina K">KG Tina</name></author><author><name sortKey="Bhadra, R" uniqKey="Bhadra R">R Bhadra</name></author><author><name sortKey="Srinivasan, N" uniqKey="Srinivasan N">N Srinivasan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, S" uniqKey="Khan S">S Khan</name></author><author><name sortKey="Vihinen, M" uniqKey="Vihinen M">M Vihinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR Whittaker</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Al Daghri, Nasser" sort="Al Daghri, Nasser" uniqKey="Al Daghri N" first="Nasser" last="Al-Daghri">Nasser Al-Daghri</name></noCountry><country name="Italie"><noRegion><name sortKey="Forni, Diego" sort="Forni, Diego" uniqKey="Forni D" first="Diego" last="Forni">Diego Forni</name></noRegion><name sortKey="Cagliani, Rachele" sort="Cagliani, Rachele" uniqKey="Cagliani R" first="Rachele" last="Cagliani">Rachele Cagliani</name><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><name sortKey="De Gioia, Luca" sort="De Gioia, Luca" uniqKey="De Gioia L" first="Luca" last="De Gioia">Luca De Gioia</name><name sortKey="Filippi, Giulia" sort="Filippi, Giulia" uniqKey="Filippi G" first="Giulia" last="Filippi">Giulia Filippi</name><name sortKey="Pozzoli, Uberto" sort="Pozzoli, Uberto" uniqKey="Pozzoli U" first="Uberto" last="Pozzoli">Uberto Pozzoli</name><name sortKey="Sironi, Manuela" sort="Sironi, Manuela" uniqKey="Sironi M" first="Manuela" last="Sironi">Manuela Sironi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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